abstract：BACKGROUND:An adequately powered, double-blind, multisite, randomised controlled trial has shown no net clinical benefit for subcutaneous ketamine over placebo in the management of cancer pain refractory to combination opioid and co-analgesic therapy. The results of the trial were disseminated widely both nationally an...

journal_title：Internal medicine journal

authors： Hardy JR,Spruyt O,Quinn SJ,Devilee LR,Currow DC

更新日期：2014-06-01 00:00:00

abstract：:This pilot study in a prospective cohort of 20 cryptogenic stroke patients showed that a significant proportion has paroxysmal atrial fibrillation undetected by 24-h Holter monitoring. However, longer monitoring with 28-day Holter was poorly tolerated and still insufficiently sensitive for paroxysmal atrial fibrillati...

journal_title：Internal medicine journal

authors： Tu HT,Spence S,Kalman JM,Davis SM

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Both low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) have been shown to be equivalent in efficacy and safety profiles for the management of pulmonary embolism (PE). AIMS:To assess the real world management of anticoagulation in PE in a tertiary hospital setting. METHODS:An audit of pat...

journal_title：Internal medicine journal

authors： Khor YH,Smith R,McDonald CF

更新日期：2014-04-01 00:00:00

abstract：:Extramedullary haemopoiesis (EMH) is a complication commonly associated with beta-thalassaemia intermedia; it is frequently asymptomatic but can sometimes lead to symptomatic tumour-like masses. No guidelines or common consensus are available in literature regarding the different treatment strategies and only single c...

journal_title：Internal medicine journal

authors： Ruo Redda MG,Allis S,Reali A,Bartoncini S,Roggero S,Anglesio SM,Piga A

更新日期：2014-04-01 00:00:00

abstract：AIMS:To assess the level of evidence-based drug prescribing for acute coronary syndrome (ACS) at discharge from Western Australian (WA) hospitals and determine predictors of such prescribing in Aboriginal and non-Aboriginal patients. METHODS:All Aboriginal (2002-2004) and a random sample of non-Aboriginal (2003) hospi...

journal_title：Internal medicine journal

authors： Gausia K,Katzenellenbogen JM,Sanfilippo FM,Knuiman MW,Thompson PL,Hobbs MS,Thompson SC

更新日期：2014-04-01 00:00:00

abstract：AIM:To explore and detail clinical experiences of dabigatran, a novel anticoagulant, after it became available in New Zealand in July 2011. METHODS:A cohort of patients was recruited from Hutt Hospital and the two largest primary care practices in the Hutt Valley region. They were included if they took at least one do...

journal_title：Internal medicine journal

authors： Thorne K,Jayathissa S,Dee S,Briggs N,Taylor J,Reid S,De Silva K,Dean J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Advance care planning (ACP) provides patients with the ability to make their decisions known about how they would like to be treated if they lose capacity. Medical practitioners have a key role to play in providing information on ACP to their patients. This research explores their knowledge and attitudes to ...

journal_title：Internal medicine journal

authors： Cartwright C,Montgomery J,Rhee J,Zwar N,Banbury A

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Acute poisoning accounts for a significant proportion of the total burden of disease worldwide. While the rate of poisoning fatalities in New Zealand is comparable to other industrialised countries, demographic trends in incidence, particularly including socio-economic indicators and substances involved, are...

journal_title：Internal medicine journal

authors： Peiris-John R,Kool B,Ameratunga S

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Surveillance for colorectal neoplasia in inflammatory bowel disease (IBD) is widely practised despite a lack of convincing mortality reduction. The psychological impact of this approach is largely unexplored. AIM:To examine psychological well-being among IBD subjects undergoing colonoscopic surveillance for...

journal_title：Internal medicine journal

authors： Mountifield R,Bampton P,Prosser R,Mikocka-Walus A,Andrews JM

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:As direct-to-consumer personal genome testing (DTC-PGT) is increasingly available in Australia, knowledge of Australians' perceptions and attitudes towards this technology is needed in order to assess the (potential) impact it might have on the Australian public and healthcare system. AIMS:To explore the kn...

journal_title：Internal medicine journal

authors： Savard J,Mooney-Somers J,Newson AJ,Kerridge I

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:To identify the underlying heart disease and microbiological pathogen associated with infective endocarditis (IE) in Chinese patients in one university hospital over a 10-year period. METHODS:We recruited 115 adult patients admitted to Peking University First Hospital from 2002 to 2011 who were diag...

journal_title：Internal medicine journal

authors： Ma XZ,Li XY,Que CL,Lv Y

更新日期：2013-12-01 00:00:00

abstract：:The move by the Medical Board of Australia to commence a conversation with the medical profession about revalidation reflects that patient-centred care is at the heart of good medical practice. Patients judge their doctors' commitment to them based on whether their individual interactions with doctors meet their needs...

journal_title：Internal medicine journal

authors： Phelps G,Dalton S

更新日期：2013-11-01 00:00:00

abstract：:5-aminosalicylates (5-ASA) remain an important strategy in the induction and maintenance of remission of inflammatory bowel diseases especially in ulcerative colitis. The prototypical drug of this class, sulfasalazine is generally well tolerated with severe hypersensitivity reactions and hepatotoxicity also described ...

journal_title：Internal medicine journal

authors： Kong LM,Fok KC,Tsui A,Qian C,Fisher L

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The 2001 National Health and Medical Research Council/Australasian Society of Blood Transfusion Clinical Practice Guidelines for cryoprecipitate are being updated, and cryoprecipitate has been incorporated into new Patient Blood Management modules. AIMS:This clinical audit sought to clarify current cryoprec...

journal_title：Internal medicine journal

authors： Anderson MA,Glazebrook B,Cutts B,Stevenson L,Bielby L,Borosak M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The risks are unknown for developing chronic gastrointestinal illness when personnel are relocated short term to other countries and when taking antibiotic prophylaxis in areas where malaria is endemic. AIM:To examine the associations of deployment to developed or developing countries and exposure to doxycy...

journal_title：Internal medicine journal

authors： Lee TW,Russell L,Deng M,Gibson PR

更新日期：2013-08-01 00:00:00

abstract：:To improve organ donation processes and outcomes, many Australian hospitals have introduced donation after cardiac death (DCD) following the 2010 publication of the National Protocol for DCD. As emergency clinicians play a significant role in identifying potential DCD donors, it is critical to assess their support and...

journal_title：Internal medicine journal

authors： Marck CH,Neate SL,Weiland TJ,Hickey BB,Jelinek GA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The current results on the diagnostic accuracy of multidetector computed tomography (MDCT) in the detection of left atrial/left atrial appendage (LA/LAA) thrombus are conflicting. AIM:The aim of the present study was to determine the diagnostic accuracy of MDCT in LA/LAA thrombus with meta-ana...

journal_title：Internal medicine journal

authors： Ning Z,Min ZG,Jiang HX,Hu BL

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND/AIM:Little is known about exposures to low radiation doses in the first trimester of pregnancy and deterministic adverse effects in the offspring, and risks are extrapolated from catastrophic events or from exposures to radiotherapy. The study aimed to assess the foetal and neonatal outcomes of pregnant wome...

journal_title：Internal medicine journal

authors： Choi JS,Han JY,Ahn HK,Ryu HM,Kim MY,Chung JH,An GH,Nava-Ocampo AA

更新日期：2013-05-01 00:00:00

abstract：:Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...

journal_title：Internal medicine journal

authors： Song Y,Liu J,Li H,Zeng Z,Bian X,Wang S

更新日期：2013-05-01 00:00:00

abstract：:Transient ischaemic attack (TIA) if untreated carries a high risk of early stroke and is associated with poorer long-term survival. There have been recent advances in the understanding of TIA, its investigations, management and organisation of services for patient care. Clinically, patients are diagnosed TIA if they h...

journal_title：Internal medicine journal

authors： Phan TG,Sanders L,Srikanth V

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Advanced training in gastroenterology currently consists of 2 years of core training and 1 elective (non-core) year. We surveyed gastroenterologists 2-7 years following completion of training to determine the strengths and weaknesses of their training. METHODS:All gastroenterologists were invited to partici...

journal_title：Internal medicine journal

authors： Leung C,De Cruz P,Jones A,Sliwka G,Bell SJ,Hebbard GS

更新日期：2013-04-01 00:00:00

abstract：:The incidence of tuberculosis in the non-indigenous Australian population is low. However, in this paper we report on three cases of cavitating disease, which seem to be associated with a common illicit drug habit namely smoking marijuana using a makeshift pipe or bong. There was a total of 34 positive contacts of the...

journal_title：Internal medicine journal

authors： Thu K,Hayes M,Miles S,Tierney L,Foy A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND/AIM:Although induction chemotherapy comprising high-dose cytarabine (HiDAC) in combination with idarubicin and etoposide or 'ICE' for adult acute myeloid leukaemia (AML) produces a complete remission rate of nearly 80%, gastrointestinal toxicity is significant. Omission of etoposide may produce similar clini...

journal_title：Internal medicine journal

authors： Low M,Lee D,Coutsouvelis J,Patil S,Opat S,Walker P,Schwarer A,Salem H,Avery S,Spencer A,Wei A

更新日期：2013-03-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) is a potentially fatal complication in solid organ and bone marrow transplant patients, with reported incidence of 0.5-3% and mortality of about 75%. To emphasise the importance of early diagnosis and prompt commencement of therapy results in improved clinical outcomes. A retrospective...

journal_title：Internal medicine journal

authors： Nwaba A,MacQuillan G,Adams LA,Garas G,Delriviere L,Augustson B,DeBoer B,Moody H,Jeffrey GP

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The thiopurines azathioprine and 6-mercaptopurine are recommended for maintenance of remission in inflammatory bowel disease (IBD). Measurement of concentrations of the metabolites 6-thioguanine nucleotide and 6-methylmercaptopurine helps delineate interindividual variation in metabolism that may underlie va...

journal_title：Internal medicine journal

authors： Kennedy NA,Asser TL,Mountifield RE,Doogue MP,Andrews JM,Bampton PA

更新日期：2013-03-01 00:00:00

abstract：:The incidence and prevalence of autoimmune diseases such as rheumatoid arthritis, primary Sjögren syndrome, scleroderma and systemic lupus erythematosus (SLE) varies with geography and ethnicity. For example, SLE is reported to be more common in populations such as African-Caribbeans and Indigenous Australians (IA). A...

journal_title：Internal medicine journal

authors： Vincent FB,Bourke P,Morand EF,Mackay F,Bossingham D

更新日期：2013-03-01 00:00:00

abstract：:Vancomycin remains a clinically useful antibiotic despite the advent of several alternative drugs. Optimising vancomycin therapy with therapeutic drug monitoring is widely recommended. The aim of therapeutic drug monitoring is to help the clinician to achieve target pharmacodynamic parameters in the case of vancomycin...

journal_title：Internal medicine journal

authors： Avent ML,Vaska VL,Rogers BA,Cheng AC,van Hal SJ,Holmes NE,Howden BP,Paterson DL

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Where proven cancer therapies remain unfunded, patients are faced with difficult decisions regarding personally covering some or all of the treatment cost. Clinical trials provide an alternative form of access to unfunded drugs. AIMS:To examine the patient population and utilisation of the colorectal cancer...

journal_title：Internal medicine journal

authors： Tie J,Gibbs P

更新日期：2013-01-01 00:00:00

abstract：:The insulin tolerance test is considered the gold standard for assessing the hypothalamic-pituitary-adrenal and growth hormone (GH) axes, but its use varies considerably among different endocrine units. We recommend using the insulin tolerance test to assess the hypothalamic-pituitary-adrenal axis within 3 months of p...

journal_title：Internal medicine journal

authors： Sarlos S,Inder WJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Timely administration of intravenous tissue plasminogen activator (IVtPA) for acute ischaemic stroke is associated with better clinical outcomes. Therefore, a coordinated hospital system of acute clinical assessment and neuroimaging will likely avoid delays in IV-tPA administration. AIM:In July 2007, we imp...

journal_title：Internal medicine journal

authors： Tai YJ,Weir L,Hand P,Davis S,Yan B

更新日期：2012-12-01 00:00:00

abstract：:A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on ...

journal_title：Internal medicine journal

authors： Don GW,Joseph F,Celermajer DS,Corte TJ

更新日期：2012-12-01 00:00:00

abstract：:Despite the inclusion of investigator-industry pecuniary and non-pecuniary associations in published clinical trials, the benefit of such disclosures may be limited. Two recent pivotal phase III drug studies that raised conflict of interest issues are discussed. It is recommended that in the future, a firewall should ...

journal_title：Internal medicine journal

authors： Carney SL

更新日期：2012-11-01 00:00:00

abstract：:The mortality rate post admission to hospital after successful resuscitation from out-of-hospital cardiac arrest is high, with significant variation between regions and individual institutions. While prehospital factors such as age, bystander cardiopulmonary resuscitation and total cardiac arrest time are known to inf...

journal_title：Internal medicine journal

authors： Stub D,Bernard S,Smith K,Bray JE,Cameron P,Duffy SJ,Kaye DM

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Many studies support the role of bilirubin as a cytoprotector in chronic inflammatory diseases, such as stroke and atherosclerosis. AIM:To investigate the relationship between serum total bilirubin levels and functional dependence in older adults. METHODS:Data from the National Health and Nutrition Examina...

journal_title：Internal medicine journal

authors： Kao TW,Chou CH,Wang CC,Chou CC,Hu J,Chen WL

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS), a haematological disorder of the elderly, has been formally classified as a neoplastic disease for 10 years. AIMS:Our aim was to collate national cancer registry incidence data to describe the epidemiology of MDS in New Zealand. METHODS:The New Zealand Cancer Registry has no...

journal_title：Internal medicine journal

authors： Rodger EJ,Morison IM

更新日期：2012-11-01 00:00:00

abstract：AIMS:We sought to assess a broad array of possible precipitants of acute coronary syndromes (ACS) and evaluate their association with detectable inflammatory activation. METHODS AND RESULTS:Within a case-crossover design, using a standardised questionnaire, interviews among 348 ST-elevation myocardial infarction (44%)...

journal_title：Internal medicine journal

authors： Chew DP,Mattschoss S,Horsfall M,Astley C,Vaile JC,Joseph MX

更新日期：2012-10-01 00:00:00

abstract：:Stereotactic radiation therapy has emerged as an alternative to conventional radiotherapy for treatment of Cushing disease. The aim of this study was to investigate the efficacy and safety of this treatment. Records of patients with Cushing disease treated with stereotactic radiation were reviewed. Seventeen patients ...

journal_title：Internal medicine journal

authors： Wein L,Dally M,Bach LA

更新日期：2012-10-01 00:00:00

abstract：:Non-invasive ventilation refers to a number of respiratory support strategies commonly used in critical care settings. This paper describes the principles of non-invasive ventilation, the practicalities of its use and the evidence for its use in a number of common acute conditions. ...

journal_title：Internal medicine journal

authors： Cross AM

更新日期：2012-10-01 00:00:00

abstract：:Laura was unusual. She had always been different and at times difficult. She was born with a genetic disorder, diagnosed as 1p36 deletion syndrome when she was 21 years old. At 23 she suffered her first cardiac arrest at home and entered the hospital system for the first time apart from infancy. After initially appear...

journal_title：Internal medicine journal

authors： Tandy PA

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Tuberculous lymphadenitis is the commonest form of extrapulmonary tuberculosis. However, the optimal approach to diagnosis, employing biopsy by either fine needle aspiration (FNA) or surgical excision, remains uncertain. AIMS:To evaluate the diagnostic value of biopsy using each of the component diagnostic ...

journal_title：Internal medicine journal

authors： Knox J,Lane G,Wong JS,Trevan PG,Karunajeewa H

更新日期：2012-09-01 00:00:00